郑玉新

郑玉新，青名端子孙岛大学公共卫生学院院长，博士，首席教授，博士生导师。国家杰出青年基金获得者，山东省泰山学者特聘教授良有的。

简介

　　郑玉新，来自青岛大学公共卫生学院院长，博士，首席教授，博士生导师。国家杰出青年基金获得者，山东省泰山学者特聘教授。

　　现任国家自然科学基金委医学科学部专家咨询委员会委员、国家环境与健康咨询委员会委员、中国毒理学会监事长、中国环境诱变剂学会生物标志物专业委员会主任委员。在IPCS/WHO危险度评价咨询委员会、WHO纳米健康工作组等国际组织任咨询专家。目前担任《中华预防医学杂志》副主编以及《科学通报》等养多个国内学术期刊编委，担任TAAP和BES两个国际期刊的编委。

　　曾任中国疾病预防控制中心职业卫生与中毒控制所副所长、WHO职业卫生合作中心(北京)主任、国家职业卫生标准委员会副主任委员、中国毒理学会副理事长、中国毒理学会工业毒理专业委员会主任委员、中华预防医学会卫生毒理学360百科专业委员会主任委员等。

　　研究方向为环境有害因素对健康影响的标志物及其转化应用。曾主持完成的科研项目主要包括国家自然科学基金重点项目和面上项目、973项目、国家"十一.诗展树物划五、"、"十二.五"科技支撑项目、卫生公益性行业科研专项重点项目以及国际合作项目等。

　　获中华预防医学奖、"十一.五"国家科技计划执行突出贡献奖等奖项。主编和参编书籍6部，衣观状艺块全手管移烟发表论文300余篇。伟煤策燃独培养博士和硕士研究生40余名。

科学研究

　　一，目前执行的科研项目

　　1. 国家自然科学基金重大研究计划集成项目"大气细颗粒物健康危害的系统毒理学与系统流行病学研究 "(91943301) 2020.1-2022.照集继果计何12 主要参加者

　　2.国家自然科学基金重大研究计划河五磁头侵触杆逐重点支持项目"交通尾气颗粒物致健康损害效应的关键组分及人群生物标志物研究"(91643203)2017.1-2020.12 项目负责人

　　3.科技部重点研发计划"基于人群队列的食品污染物生物标志物研究与应用"(2017YFC1600202) 2018.01-2021.支天节项静案英台12，项目负责人

　　二、近两年发表的论文

　　1. Dai Y, Zhou W, Jia 左未态另规准死致Q, Dong H, Niu Y, He J, Bin P, Yi J, Xiang Y, Duan H, Huang H, Sha Y, Shen M, Ye M, Huang X, Zheng Y. Uti紧华顺苏府显四除lity evaluation of HLA-B*13:害零多抗定完停阿们所01 screening in preventing trichloroethylene-已离口设induced hypers款ensitivity syndrome in a prospectiv武席画率e cohort study. O侵加投巴进ccup Environ Med. 2020 图王律音运酒来常销Mar;77(3):201-206. doi: 10.1136/oemed-2019-106171. Epub 2020 Feb 5. PMID: 32024660

　　2. Chen S, Li D, W验末鸡声西降己水宽父u X, Chen L, Zhang B, Tan Y, Yu D, Niu Y, Duan H, Li Q, Ch预冷续请以流阿en R, Aschner M, Zheng Y, Chen W. A景意来却等审pplication of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int. 2020 Apr 4;139:105703. doi: 10.1016/j.envint.2020.105703. Online ahead of print. PMID: 32259755

　　3. Cui L, Shi L, Li D, Li X, Su X, Chen L, Jiang Q, Jiang M, Luo J, Ji A, Chen C, Wang J, Tang J, Pi J, Chen R, Chen W, Zhang R, Zheng Y. Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice. Front Pharmacol. 2020 Mar 31;11:199. doi: 10.3389/fphar.2020.00199. eCollection 2020. PMID: 32296328

　　4. Cheng W, Liu Y, Tang J, Duan H, Wei X, Zhang X, Yu S, Campen MJ, Han W, Rothman N, Belinsky SA, Lan Q, Zheng Y, Leng S.Carbon content in airway macrophages and genomic instability in Chinese carbon black packers. Arch Toxicol. 2020 Mar;94(3):761-771. doi: 10.1007/s00204-020-02678-6. Epub 2020 Feb 19. PMID: 32076763

　　5. Li Y, Yang M, Meng T, Niu Y, Dai Y, Zhang L, Zheng X, Jalava P, Dong G, Gao W, Zheng Y. Oxidative stress induced by ultrafine carbon black particles can elicit apoptosis in vivo and vitro. Sci Total Environ. 2020 Mar 20;709:135802. doi: 10.1016/j.scitotenv.2019. 135802. Epub 2019 Dec 17. PMID: 31887498

　　6. Zhang J, Zhou Q, Su R, Sun Z, Zhang W, Jin X, Zheng Y. Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure. Sci Total Environ. 2020 Mar 6;721:137792. doi: 10.1016/j.scitotenv.2020.137792. Online ahead of print. PMID: 32182466

　　7. Chen S, Li D, Zhang H, Yu D, Chen R, Zhang B, Tan Y, Niu Y, Duan H, Mai B,Chen S, Yu J, Luan T, Chen L, Xing X, Li Q, Xiao Y, Dong G, Niu Y, Aschner M,Zhang R, Zheng Y, Chen W. The development of a cell-based model for theassessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019 Oct;131:104943. doi: 10.1016/j.envint.2019.104943. Epub 2019 Jul 8. PubMedPMID: 31295644.

　　8. He Z, Zhang R, Chen S, Chen L, Li H, Ye L, Li Q, Wang Z, Wang Q, Duan H, NiuY, Xiao Y, Dong G, Li D, Yu D, Zheng Y, Xing X, Chen W. FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollut. 2019 Sep;252(Pt A):607-615. doi: 10.1016/j.envpol.2019.05.137. Epub 2019 May 28. PubMed PMID: 31185349.

　　9. Chu C, Zhou L, Xie H, Pei Z, Zhang M, Wu M, Zhang S, Wang L, Zhao C, Shi L,Zhang N, Niu Y, Zheng Y, Zhang R. Pulmonary toxicities from a 90-day chronicinhalation study with carbon black nanoparticles in rats related to thesystemical immune effects. Int J Nanomedicine. 2019 Apr 30;14:2995-3013. doi:10.2147/IJN.S198376. eCollection 2019. PubMed PMID: 31118618; PubMed CentralPMCID: PMC6503190.

　　10.Chen Z, Yang L, Huang Y, Spencer P, Zheng W, Zhou Y, Jiang S, Ye W, Zheng Y,Qu W. Carcinogenic risk of N-Nitrosamines in Shanghai Drinking Water: Indicationsfor the Use of Ozone Pretreatment. Environ Sci Technol. 2019 Jun18;53(12):7007-7018. doi: 10.1021/acs.est.8b07363. Epub 2019 May 24. PubMed PMID:31083987.

　　11.Wang G, Zheng X, Duan H, Dai Y, Niu Y, Gao J, Chang Z, Song X, Leng S, Tang J, Zheng Y. High-content analysis of particulate matters-induced oxidative stress and organelle dysfunction in vitro. Toxicol In Vitro. 2019 Sep; 59:263-274. doi:10.1016/j.tiv.2019.04.026. Epub 2019 Apr 25. PubMed PMID: 31029784.

　　12.Yang M, Li Y, Meng T, Zhang L, Niu Y, Dai Y, Gao W, Bloom MS, Dong G, Zheng Y. Ultrafine CB-induced small airway obstruction in CB-exposed workers and mice. Sci Total Environ. 2019 Jun 25;671:866-873. doi: 10.1016/j.scitotenv.2019.03.033.Epub 2019 Mar 16. PubMed PMID: 30947057.

　　13.Li D, Zhang R, Cui L, Chu C, Zhang H, Sun H, Luo J, Zhou L, Chen L, Cui J,Chen S, Mai B, Chen S, Yu J, Cai Z, Zhang J, Jiang Y, Aschner M, Chen R, Zheng Y, Chen W. Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environ Pollut. 2019 May; 248:874-887. doi: 10.1016/j.envpol.2019.02.097. Epub2019 Mar 2. PubMed PMID: 30856503.

　　14.Chu C, Zhang H, Cui S, Han B, Zhou L, Zhang N, Su X, Niu Y, Chen W, Chen R, Zhang R, Zheng Y. Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation. J Hazard Mater. 2019 May5; 369:180-190. doi: 10.1016/j.jhazmat.2019.02.026. Epub 2019 Feb 10. PubMed PMID:30776601.

　　15.Zheng X, Wang G, Bin P, Meng T, Niu Y, Yang M, Zhang L, Duan H, Yu T, Dai Y, Zheng Y. Time-course effects of antioxidants and phase II enzymes on diesel exhaust particles-induced oxidative damage in the mouse lung. Toxicol Appl Pharmacol. 2019 Mar 1;366:25-34. doi: 10.1016/j.taap.2019.01.010. Epub 2019 JanPubMed PMID: 30641076.

　　16.Wei Hu, Bryan A. Bassig, Yufei Dai, Dianzhi Ren, Huawei Duan, Yong Niu, Jun Xu, Wei Fu, Kees Meliefste, Baosen Zhou, Jufang Yang, Meng Ye, Xiaowei Jia, Tao Meng, Ping Bin, Jason YY Wong, Dean H. Hosgood, Nathaniel Rothman, Roel C. Vermeulen, Debra T. Silverman, Yuxin Zheng and Qing Lan. Abstract 597: Occupational exposure to diesel engine exhaust and alternations in serum microRNAs. DOI: 10.1158/1538-7445.AM2019-597

　　17.Zhiyuan Chen, Lan Yang, Ziqi Li, Yu Huang, Hao Jiang, Wuren Ma, Weiwei Zheng, Yuxin Zheng, Weidong Qu. Application of biomarkers in the study of the health effects of disinfection by-products, Current Opinion in Environmental Science & Health, Volume 7,2019,Pages 108-116,ISSN 2468-5844.

　　18.Wang H, Duan H, Meng T, Yang M, Cui L, Bin P, Dai Y, Niu Y, Shen M, Zhang L, Zheng Y, Leng S. Local and Systemic Inflammation May Mediate Diesel Engine Exhaust-Induced Lung Function Impairment in a Chinese Occupational Cohort. Toxicol Sci.2018Apr 1;162(2): 372-382. doi: 10.1093/toxsci/kfx259.

　　19.Dai Y, Ren D, Bassig BA, Vermeulen R, Hu W, Niu Y, Duan H, Ye M, Meng T, Xu J, Bin P, Shen M, Yang J, Fu W, Meliefste K, Silverman D, Rothman N, Lan Q, Zheng Y. Occupational exposure to diesel engine exhaust and serum cytokine levels. Environ Mol Mutagen.2018Mar;59(2):144-150. doi: 10.1002/em.22142. Epub 2017 Oct 12.

　　20.Zheng J, Zheng W, Zhou Y, Jiang S, Spencer P, Ye W, Zheng Y, He G, Qu W. Heavy Exposure of Waste Collectors to Polycyclic Aromatic Hydrocarbons in a Poor Rural Area of Middle China. Environ Sci Technol.2018Aug 7;52(15):8866-8875. doi: 10.1021/acs.est.8b02024. Epub2018Jul 18.

　　21.Niu Y, Zhang X, Meng T, Wang H, Bin P, Shen M, Chen W, Yu S, Leng S, Zheng Y Exposure characterization and estimation of benchmark dose for cancer biomarkers in an occupational cohort of diesel engine testers. J Expo Sci Environ Epidemiol.2018Nov;28(6):579-588. doi: 10.1038/s41370-018-0061-x. Epub2018Sep 5

　　22.Yu P, Jiao J, Chen G, Zhou W, Zhang H, Wu H, Li Y, Gu G, Zheng Y, Yu Y, Yu S. Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study. BMC Med Genet.2018Jan 5;19(1):4. doi: 10.1186/s12881-017-0515-3.

　　23.Wang Y, Duan H, Meng T, Shen M, Ji Q, Xing J, Wang Q, Wang T, Niu Y, Yu T, Liu Z, Jia H, Zhan Y, Chen W, Zhang Z, Su W, Dai Y, Zhang X, Zheng Y.Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population. Environ Int.2018Mar; 112:207-217. doi: 10.1016/j.envint.2017.12.024. Epub 2017 Dec 22.

　　24.Wang G, Zheng X, Tang J, Niu Y, Dai Y, Duan H, Zheng Y. LIN28B/let-7 axis mediates pulmonary inflammatory response induced by diesel exhaust particle exposure in mice. Toxicol Lett.2018Dec 15;299:1-10. doi: 10.1016/j.toxlet.2018.08.019. Epub2018Aug29.

　　25.Zhang C, Quan Z, Wu Q, Jin Z, Lee JH, Li C, Zheng Y, Cui L. Association between Atmospheric Particulate Pollutants and Mortality for Cardio-Cerebrovascular Diseases in Chinese Korean Population: A Case-Crossover Study. Int J Environ Res Public Health. 2018 Dec 12;15(12). pii: E2835. doi: 10.3390/ijerph15122835. PubMed PMID: 30545115; PubMed Central PMCID: PMC6313322.