安利佳

安利佳，男，现任中国遗传学会理事，中国化工学会生物工程分会理事，教育部科委生命科学学部委员，辽宁省遗传学会及生物技术学会理事。1998-2002年来自任大连理工大学生物工程系主任主要从事植物基因工程和药物生物技术研究，先后主持国家科技攻关项目1项、省、市级重大研究课题4项。

中文名称安利佳
国籍中国
毕业院校东北师范大学
主要成就辽宁省优秀青年科技工作者
大连市优秀专家
职务中国遗传学会理事

人物经历

教育经历

　　1986.9 1989.8东北师范大学植物学博士

　　19来自82.3 1984析与使拉.8东北师范大学遗传学硕士

　　360百科1978.3 1982.2辽宁师范大学生物学学士

　　1969.9 1972.8丹东市第二中学高中课程

判延道持尼粒工作经历

　　1998.感预实县蛋边证轴我记活3 至今大连理工大学教师

　　1984.10 1998.2辽宁师范大学教师

　　1975.12 1978.2丹东市陶瓷厂工人

　　1973.12 1975.12丹东市东沟县海洋红公社知青

　　1972.1赵损斤具板杀九2 1973.12丹东市凤城县赛马公社知青

社会兼职

　　2006.5至今评委(国家留学基金委)

　　2007.10至今副理事长(中国园艺学会小浆果分会)

袁坐　　2005.12020.12学部委员(教育受草况击攻染施另部科委生命科学学部)

　　2005.12020.12理事(中国遗传学会)

　　2004.122019.12专家(辽宁省生物技术协会专家委员会)

研究领域

　　1. 植物转基因工程与育种技术平台研究。编号:JY03-B-18，国来自家科技部植物转基因重大专项，100万元，2003-2004

　　2. 基因工程关键技杨铁在宗剧证超次术。项目编号:2001101001，辽宁省科技厅，210万元，2001-2004

　　3. 无载体、无标记基因植物360百科转基因技术。项目编号:200移外鲜必推圆钟3B4NS015，大连市科技肉功氢犯诗板标案修局，100万元，2003-2004

　　4. 蛇岛蝮蛇类凝血酶基因的分离和表达。辽宁省科技攻关，10万元，1999.01-2001.12

　　5. 蛇岛蝮蛇类凝血酶基因的分离和树真表达。大连市科委，15万元在增案介般，1998-2001

　　6. 胸腺素α1基因工程药物开发。通化金马制药股份公司，390万元，1998.01~2001.12

　　7. 杨树基因工呢家城程育种。鞍山生生高新植物技术应用股份有限公司，25员眼了量府演只卫万元，2001.9-2003.9

　　8. 长春花碱单体的分离研究。大连理工大学领先集团有限公司，20万元，2002.7-2003.7

　　9. 真福康保健功效的验证与鉴定。大连理工大学领先集团有限公司，10万元，2002.7-2003.7

　　指导硕、博士生研究方向:植物基因工程、生物制药

出版著作

　　五年来共发表文章120余篇，SCI收录42篇，主要文章包括:

　　1. Properties of A. ficuum AS3.324 phytase expressed in toba规期cco. Process Bioc获宪果告样般hemistry,2005,40:213–216 SCI

　　2. Purification,characterization and gene cloning of a novel phospholipase A2 from the venom of Agkist需地朝维括奏马担歌重类rodon blomhoffii ussurensis. The International Journal of Biochemical & Cell Biology. 2005,37:558-565 SCI

　　3. Neuroprotective properti影晚江编坐es of catalpol in transient glob弦al cerebral ischemia in gerbils: dose-response,therapeutic time-window and long-term effica居告探最已季波善端月cy. Brain Research,2004,1029:179-185 SCI

　　4. Plasmodiu现应思m falciparum his修继宁略陆tone acetyltransferase,a yeast GCN5 homolog九晚短意路屋消日ue involved in chromatin remodeling. Eukaryotic Cell,2004,3(2):264-276

　　5. Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 ce现粮套生规lls by prev倍速增商enting cytochrome c release and inactivating of caspase casecade. Toxicon,2004,43:53-59

　　6. PfADA2,a Plasmodium falciparum homologue of the transcriptional coactivator ADA2 and its in vivo association with the histone acetyltransferase PfGCN5. Gene,2004,336:251-261

　　7. Construction of Targeting Vector and Expression of Green Fluorescent Protein in the Silkworm,Antheraea pernyi. DNA and Cell Biology. 2003,22:441-446

　　8. The Expression of GFP Under the Control of Fibroin Promotor in Primary ovarian cells of Antheraea pernyi. Journal of Biosciences,2003,28(6):691-695

　　9. 菟丝子提取物在PC12细胞株中的神经营养因子样活性。生物化学与生物物理进展。2003,30(2):226-230

　　10. Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells. Acta Pharmacologica Sinica,2003,24(9):913-917

　　11. Effect of Cuscuta chinensis glycoside on the neuronal differentiation of rat pheochromocytoma PC12 cells. International Journal of Developmental Neuroscience,2003,21:277-281

　　12. Hydrogen peroxide-induced apoptosis in PC12 cells and the protective effect of puerarin. Cell Biology International,2003,27:1025-1031

　　13. Neuroprotective effect of Alpinia oxyphylla Miq. fruits against glutamate-induced apoptosis in cortical neurons. Toxicology Letters,2003,144(2):205–212

　　14. Neuroprotective effect of Alpinia oxyphylla extract against glutamate excitotoxicity in cultured mouse cortical neurons. Neurosci Res Commun,2003,33(2):105–113

　　15. Investigation of the neuronal death mode induced by glutamate treatment in serum-,antioxidant-free primary cultured cortical neurons. Developmental Brain Research,2003,145(2):263-268

　　16. A new way for chemical degradation of plastic by natural volatile constituents of Ledum palustre. Chinese Science Bulletin,2003,48(16):1718-1721

　　17. Enhancing ethanol tolerance of a self-flocculating fusant of Schizosaccharomyces pombe and Saccharomyces cerevisiae by Mg2+ via reduction in plasma membrane permeability. Biotechnology Letters,2003,25:1191-1194

　　18. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. The Journal Of Pharmacology and Experimental Therapeutics,2003,305(1):212-218

　　19. 酸性水溶液中硫氰酸钼(V)配合物的研究。光谱学与光谱分析，2003,23(2)337-339

　　20. Purification and characterization of ulva pertusa kjellm alkaline phosphatase. Preparative Biochemistry & Biotechnology,2003,33(2):113-123

　　21. Cloning of cDNA Encoding Choline Monooxygenase from Suaeda liaotungensis and Salt Tolerance of Transgenic Tobacco. Acta Botanica Sinica,2003,45(2):242-247

　　22. Molecular cloning and characterization of betaine aldehyde dehydrogenase gene from Suaeda liaotungensis and its use in improved tolerance to salinity in transgenic tobacco. Biotechnol Lett. 2003,25(17):1431-1436

　　23. Characterization of Sporothric schenckii by random amplication of polymorphic DNA assay. Chinese Medicine Journal,2003,116(2):239-242

　　24. Expression of gloshedobin,a thrombin-like enzyme from the venom of Gloydius shedaoensis,in Escherichia coli. Biotechnology Letters,2003,25(2):101–104

　　25. High-level expression of a soluble snake venom enzyme,gloshedobin,in E. coli in the presence of metal ions. Biotechnology Letters,2003,25(8):607–610

　　26. Purification and characterization of ginsenoside--arabinofuranase hydrolyzing ginsenoside Rc into Rd from the fresh root of Panax ginseng. Process Biochemistry,2002,37:793-798

　　27. Cloning and Expression of defibrase cDNA from the venom of Gloydius shedaoensis. Biotechnology Letters,2002,24:135-138

　　28. Cloning Expression and Purification of Gussrobin A Thrombin-like Enzyme from the Snake Venom of Gloydius ussuriensis. Prog Biochem Biophys. 2002,34(1):6-10

　　29. Expression,Purification and Partial Characterization of Recombinant Defibrase,a Thrombin-Like Enzyme from the Venom of Glyodius shedaoensis. Prog Biochem Biophys. 2002,29(3)390-393

　　30. Production of a Functional Single-chain Fv Protein in Transgenic Tobacco Root Exudates. Biotechnology letters. 2002,24(18):1531-1534

　　31. An expeditious method for constructing T-vectors using Eam 1105 Ⅰ cassettes. Plant Molecular Biology Reporter,2002,20:189a-189e

　　32. Application of DNA sequencing in detection of telomerase activity. Biochemical Engineering Journal. 2002,11(2-3):79-85

　　33. Production of high affinity human single-chain antibody against preS1 of Hepatitis B Virus: comparison of large naïve and in vitro immune phage displayed antibody library. Progressing in Biochemistry and Biophysics. 2002,29(4):572-575

　　34. Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons. Journal of Pharmacology and Experimental Therapeutics,2002,302(3):1212-1219

　　35. A Serum- and Antioxidant-free Primary Culture Model of Mouse Cortical Neurons for Pharmacological Screen and Studies of Neurotrophic and Neuroprotective Agents. Cellular and Molecular Neurobiology. 2002,22(2):197-206

　　36. Expression of endoplasmic reticulum molecular chaperon GRP94 in human lung cancer tissues and its clinical significance. Chinese Medical Journal,2002,115(11):1615-1619

　　37. Embryonic stem cell as nuclear donor could promote in vitro development of the heterogeneous reconstructed embryo. Chinese Science Bulletin,2002,47(21):1811-1815

　　38. 铜锌超氧化物歧化酶与色氨酸钴(Ⅱ)的相互作用。光谱学与光谱分析，2000,3:305-307

　　39. 紫外-可见吸收光谱法测定配合显色反应的焓变。光谱学与光谱分析，2001,21(4):527-528

　　40. Kinetics of Inactivation of Ulva pertusa Kjellm Alkaline Phosphatase by Ethylenediaminetetraacetic Acid Disodium. Journal of Enzyme Inhibition,2001,16:313-319

　　41. Purification and Characterization of ginsenoside-?-Glucosidase from Ginseng. Chem. Pharm. Bull,2001,49(7):795-798

　　42. 分光光度法研究EDTA对小牛肠碱性磷酸酶的不可逆抑制动力。光谱学与光谱分析，2001,21(5):701-703

　　43. 碱性磷酸梅与Cu (Ⅱ) 相互作用的谱学研究。光谱学与光谱分析，2001,21(4):432-434

　　44. 氨基酰化酶与Cu(Ⅱ)相互作用的谱学研究。光谱学与光谱分析，2001,21(6):804-806

　　45. 可见光谱学研究核酸酶P1与氯化铜(Ⅱ)的相互作用。光谱学与光谱分析，2000,20(3):308-310

　　46. 大连蛇岛蝮蛇类凝血酶基因克隆与表达研究。大连理工大学学报，2003,43(2):156-159

　　47. 新的重组蛋白表达系统--植物根分泌和叶分泌。生物化学与生物物理进展，2003,30(1):128

　　48. 抗乙肝病毒表面抗原PreS1(20-47)的单链抗体在转基因烟草根分泌物中的初步表达。高技术通讯，2003,13(9):35-38

　　49. Variation and characterization analysis of partial fragment of fibroin gene from silkworm,Antheraea pernyi. High Technology Letters,2003,9(3):29-32

　　50. 喜树碱生物合成途径及其代谢调控的研究进展。高技术通讯，2004,14(5):106-110

　　51. 菟丝子提取物对PC12细胞中GAP-43表达影响。大连理工大学学报，2004,44(3):378-382

　　52. Rapid Amplification of 5′cDNA End of Suaeda liaotungensis Choline Monooxygenase Using Inverse PCR RACE. High Technol Lett 2002,8(1):5-7

　　53. Separation and purification of betaine aldehyde dehydrogenase from wild Suaeda liaotungensis. High Technology Letters,2002,8(2):5-17

　　54. Cloning a Full-length cDNA Encoding UDP-glucose Pyrophosphorylase from Amorpha Fruticosa by PCR-Based Methods. High Technology Letters,2002,8(3):5-10

　　55. An Lijia. A co-expression system based on phage and phagemid to select cognate antibody-antigen pairs in vivo. High Technology Letters,2002,8(2):5-10

　　56. Construction of Large Human Single-chain Antibody Phage Display Library. High Technology Letters,2002,8(3):1-4

　　57. 精子干细胞转染法制备转基因兔的研究。高技术通讯，2001,11(130):17-21

　　58. 反向嵌套PCR高效扩增辽宁碱蓬甜菜碱醛脱氢酶cDNA 5'末端序列。高技术通讯，2001,1(11):17-19

　　59. Research on telomerase detection of activity by combining DNA sequence analysis with TRAP. High Technology Letters,2001,7(3):8-10

　　60. 新型染料配基对碱性磷酸酶的亲合纯化。高校化学工程学报，2001,5(6):563-567

　　61. Separation and Purification of Thrombin-like Enzyme by Affinity Adsorbents. High Technology Letters，2001,7(4):13-15

　　62. 卵黄免疫球蛋白配基亲和纯化碱性磷酸酶。中国农业科学，2004,37(6):908-911

科研成果

　　共承担国家、省、市课题10项，项目经费总计900万元;

　　申报国内外专利13项，其中国际专利1项;

　　由安利佳教授为负责人完成的"一种植物分子育种新技术的建立与应用"项目鉴定会，于2004年12月19日通过了辽宁省科技厅科技成果鉴定，达到了国际领先水平。

　　所主持的辽宁省科技厅项目"基因工程关键技术"和大连市科技局项目"无载体、无标记基因植物转基因技术"于2004年4月6日通过了辽宁省科技厅科技成果验收和大连市科技局科技成果鉴定，达到了国际先进水平。

获得荣誉

　　2004年安利佳教授率领的课题组被学校评为大连理工大学科研创新团队。

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安利佳