田景奎

主要从事生物医药信息工程与创新药物研究工作。近3年来，开展了圆锥铁线莲、青蒿、来自银杏叶和红豆杉等10余种药用植物的活性酶诱导实验，并研制出智能活性酶诱导仪;进而运用蛋白质组、基因组和生物信息学技术对银杏叶、圆锥铁线莲和红豆杉等进行了活性成分生物合成机理的研究360百科;开展了三维组断商解力世晚书大织芯片的系统研究，进行了芯类绝批参行调田护呀片构建和复杂信号处理研究，为新药筛选和作用机制研究奠定了基础;从20余种药用信音货植物中分离得到500多个化合物，其中70多个新化合物，对新化合物中特有的抗肿瘤、抗结核和抗炎活性成分进行了作用机制探讨;开展了创新药物研究，获得临床批件2项，在研新药和健康相关产品10余项。正在承担国家自然科学基金、新药创制国家重大科技专项、浙江省重大科技专项、浙江省杰出青年基金和教育部博士点基金等项目。已在国内外重要刊物发表文章70余篇，其中SCI收录30余篇。

• 中文名称 田景奎
• 毕业院校 中国协和医科大学
• 学位/学历 博士
• 专业方向 生物医药信息工程、系统生物学、天然药物开发
• 职务 医疗健康信息工程技术研究所副所长

科研项目

来自　　1.浙江省国职茶沙地秋按挥续际科技合作"一带一路"专360百科项，浙江-马来西亚传统药物联合研究中心，在研

　　2.国家新药创制重大专项，基于脐融透皮给药关键技术的中药新药*** ，在研

　　3.国家自然基金，维药野胡萝卜子中Dau早做说况医青初液喜cusol的定向分离及其抗肿瘤耐药作用机理的研究，结题

　　4.国家自然基金，基于紫外诱导圆锥铁线莲叶绿体内抗肿瘤香豆素生物合成关键酶与关键基因研究，结题

　　5.浙江省自然基金重点项目，桑叶中抗BmNPV活性的Diels-Alder加合著目特写培均物的诱导及其生物合成机句制研究，结题

　　6.教育部科学技术重点项目，基于紫外诱导桑叶中Diels-Alder加合物生物合成关键基因、关键酶及其应用研究，结题

　　7.国家新药创制重大专项，抗肿瘤中药新药***的临床前研究定讨基定川旧(滚动)，结题

　　8.国家新粒菜销元何晶士药创制重大专项，抗结核中药新药***的临床前研究(滚动)，结题

　　院法冷代示赶意谈季9.教育部博士点基金，基于板亚细胞水平紫外诱导圆锥铁线莲香豆素生物合成机制的研究，结题

　　10.浙江省自然基金杰出青年基金，基于光酶诱导银杏工叶中抗氧化活性成分的生物合成机制研究，结题

出版著作

　　孔令义，田景奎等。天然药物化学，化学工业出版社，2018.5

　　杨世林，田景奎等。天然产物化学研究，科学技术出版社，2010.10

奖励荣誉

　　田景奎，张琳，马胜林，等。中药新药辛萸贴片研究，浙江省科技进步三等奖，2010年

专利成果

　　1. 从中药圆锥铁线莲中分离纯化活性成分金色酰胺醇酯的方法，ZL2010106063805，2014.声调01.29

　　2.一种墨旱莲提取物的制备方法及用途，ZL201101845891, 2013.01.23

　　3.一种治疗偏头痛的中药复方制剂及其制备方法，ZL2010106063839, 2012.04.25

　　4. 运用活性酶诱导技术提高黄花蒿中青蒿素含量的方法，ZL2010来自10186313, 2012.01.11

　　衡件奏先听来简右5. 一种细梗香草皂苷A的制备方法及其用途，CN201510505992.8, 2015.08.18

　　6.一种防治高血脂的重要组合物及其制备方法，CN201510755417360百科.3, 2015.11.05

　　7.一种东个担制对法双义级革阿里提取物及其制备方法，CN20150906420.0, 2015.12.07

　　8.一种防治家蚕BmNPV病的诱导桑叶及其用途， CN201710252959前即作将凯系轻际酒差激.8, 2017.04年拉.18

研究成果

1. Guan QJ, Yu JJ, Zhu W, Yang BX, Li YH, Zhang L, Ti免输受操an JK*. RNA-Seq transcriptome analysis of the Morus alba L. leaves exposed to high-level UV-B with and without dark treatment. Gene 2018, 645:60-68
2. Han HT, Chou CC, Li RY, Liu JY, Zhang L, Zhu W, H未甚u J, Yang BX, Tian JK*. Chalc校绿卷汽型左omoracin is a potent anticancer agent through triggering oxidative stress via a mitophagy-dependent mechanism. Sci. Rep. 2018, 8(培地号绍亚早司最铁板失1): 9566
3. Zhu W, Zheng W, Hu XJ, Xu XB, Zhang L, Tian JK*. Var了信化伯况派部注吧胜iations of metabolites and proteome in Lonicera japonica Thunb. buds and 担又开就flowers under UV radiation. B斯愿房宜物毛BA-Proteins and Proteom. 2017, 1865(4): 404-413.
4. Ren YN, Xu XB, Zhang QL, Lu YZ, 免成的技顺态代系镇适Li XM, Zha防均村ng L, Tian JK*. Iso厚天额lation, characterization, and in rats plasma pharmacokinetic study of a new triterpen存苗践误虽面本oid saponin from D简倒激呼介定好断笑底倍ianthus sup势抓境南势剂erbus. Arch. Pharm. Res. 2017, 40(2): 159-167.
5. Hashiguchi A.*, Hitachi K., Zhu W., Tian JK, Tsuchida K., Komatsu S. Mung bean (Vigna radiata (L.)) coat extract modulates macrophage functions to enhance antigen presentation: A proteomic study. J. Proteomics 2017, 161: 26-37.
6. Zhang DD, Gao CX, Li RY, Zhang L, Tian JK. TEOA, a triterpenoid from Actinidia eriantha induces autophagy in SW620 cells via endoplasmic reticulum stress and ROS-dependent mitophagy. Arch. Pharm. Res. 2017, 40(5): 579-591.
7. Hu J#, Zhu W#, Yaohan Li, Guan QJ, Haijian Yan, Yu JJ, Fu ZR, Lu XM, Tian JK*. SWATH-based quantitative proteomics reveals the mechanism of enhanced Bombyx mori nucleopolyhedrovirus-resistance in silkworm reared on UV-B treated mulberry leaves. Proteomics 2017, 17(13-14): 1600383.
8. Wang X, Zhu W, Hashiguchi A, Nishimura M, Tian JK, Komatsu S*. Metabolic profiles of flooding-tolerant mechanism in early-stage soybean responding to initial stress. Plant Mol. Biol. 2017, 94: 669-685.
9. Hashiguchi A.*, Zhu W., Tian JK, Komatsu S.* Proteomics and metabolomics-driven pathway reconstruction of mung bean for nutraceutical evaluation. BBA-proteins and proteom. 2017, 1865(8): 1057-1066.
10. Feng HJ, Yang YL, Sun SC, Li YJ, Zhang L, Tian JK, Zhu QH, Feng ZL, Zhu HQ*, Sun J*. Molecular analysis of caffeoyl residues related to pigmentation in green cotton fibers. J. Exp. Bot. 2017, 68(16): 4559-4569.
11. Yang BX, Guan QJ, Tian JK*, Komatsu S. Transcriptomic and proteomic analyses of leaves from Clematis terniflora DC. under high level of ultraviolet-B irradiation followed by dark treatment. J. Proteomics 2017, 150: 323-340.
12. Hu J, Wang J, Li SX, Yang BX, Gong MH, Li XM, Zhang L, Tian JK*. Phytochemical compositions, antioxidant and antimicrobial activities analysis of extracts from Vaccinium bracteatum Thunb. leaves. J. Appl. Bot. Food Qual. 2016, 89: 150-155.
13. Yang BX, Wang X, Gao CX, Chen M, Guan QJ, Tian JK*, Komatsu S. Proteomic and Metabolomic Analyses of Leaf from Clematis terniflora DC. Exposed to High-Level Ultraviolet B Irradiation with Dark Treatment. J. Proteome Res. 2016, 15: 2643-2657.
14. Zheng W, Lu XH, Fu ZR, Zhang L, Li XM, Xu XX, Ren YN, Lu YZ, Fu HW, Tian JK*. Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis. BBA-Protein and Proteom. 2016, 1864: 308-316.
15. Li MZ, Yang BX, Chen QY, Zhu W, Ma J, Tian JK*. The complete chloroplast genome sequence of Clematis terniflora DC. (Ranunculaceae). Mitochondrial DNA Part A 2016, 27(4): 2470-2472.
16. Chen QY, Feng X, Li MZ, Yang BX, Gao CX, Zhang L, Tian JK. The complete chloroplast genome sequence of Fatsia japonica (Apiales: Araliaceae) and the phylogenetic analysis. Mitochondrial DNA Part A 2016, 27(4): 3050-3051.
17. Zhu W, Xu XB, Tian JK, Zhang L, Komatsu S. Proteomic Analysis of Lonicera japonica Thunb. Immature Flower Buds Using Combinatorial Peptide Ligand Libraries and Polyethylene Glycol Fractionation. J. Proteome Res. 2016, 15: 166-181.
18. Xu XB, Gao BB, Guan QJ, Zhang DD, Ye XH, Zhou L, Tong GX, Li H, Zhang L, Tian JK*, Huang JY. Metabolomic profile for the early detection of coronary artery disease by using UPLC-QTOF/MS. J. Pharm. Biomed. Anal 2016, 129: 34-42.
19. Shen LQ, Guan QJ, Amin A, Zhu W, Li MZ, Li XM, Zhang L, Tian JK*. Complete plastid genome of Eriobotrya japonica Thunb. Lindl and comparative analysis in Rosaceae. SpringerPlus 2016, 5: 2036
20. Zheng W, Komatsu S, Zhu W, Zhang L, Li XM, Cui L, Tian JK*. Response and Defense Mechanisms of Taxus chinensis leaves under UV-A Radiation are Revealed Using Comparative Proteomics and Metabolomics Analyses. Plant & Cell Physiol. 2016, 57(9): 1839-1853.
21. Chen ZZ, Zhou X, Hu BY, Li WY, Chen GY, Zhang Y, Tian JK, Zhang L, Li M, Jiang HL. Tissue distribution of capilliposide B, capilliposide C and their bioactive metabolite in mice using liquid-tandem mass spectrometry. Biomed. Chromatogr. 2016, e3895.
22. Gao CX, Yang BX, Zhang DD, Chen M, Tian JK*. Enhanced metabolic process to indole alkaloids in Clematis terniflora DC. after exposure to high level UV-B irradiation follow by the dark. BMC Plant Biol. 2016, 16: 231
23. Zheng W, Li XM, Zhang L, Zhang YZ, Lu XP, Tian JK*. Improved metabolites of pharmaceutical ingredient grade Ginkgo biloba and the correlated proteomics analysis. Proteomics 2015, 15(11): 1868-1883.
24. Xu JK, Lu XH, Zhu W, Yang BX, Zhang L, Tian JK*. Two new eudesmane-type glucopyranosides from the fruits of Daucus carota L. Nat. Prod. Res. 2015, 29(20): 1903-1908.
25. Xu CJ, Yang BX, Zhu W, Li XM, Tian JK, Zhang L. Characterization of polyphenol constituents in leaves of Linderae aggregate and their antioxidant activities. Food Chem. 2015, 186: 83-89.
26. Yang Y, Zhang LH, Yang BX, Tian JK, Zhang L* .Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo through activating autophagy. J. Cell. Mol. Med. 2015, 19(5): 1055-1064.
27. Fu ZZ, Han HT, Liu N, Xu XB, Zhu W, Gong MH, Zhang L, Tian JK*. Two new eudesmane sesquiterpenoids from Daucus carota L. Phytochem. Lett., 2015, 14: 35-38.
28. Liu XB, Yang BX, Zhang L, Lu YZ, Gong MH, Tian JK*. In vivo and in vitro the anti-inflammatory and antinociceptive activities of the ethanol extract fraction and aurantiamide acetate from Clematis terniflora DC. J. Ethnopharmacol. 2015,134(3): 1018-1023.
29. Zhu W, Hu J, Wang X, Tian JK*, Komatsu S. Organ-specific analysis of Mahonia using Gel-free/Label-free proteomic technique. J. Proteome Res. 2015, 14(6): 2669-2685.
30. Zhu W, Yang BX, Komatsu S, Lu XP, Li XM, Tian JK*. Gel-Free Quantitative Proteomic Analysis of Catharanthus roseus Seedlings with Induction of Indole Alkaloids. Front. Plant Sci. 2015, 6: 582。